revalence of the American College of heumatology hematological classification criteria nd associations with serological and clinical ariables in 460 systemic lupus erythematosus atients

Objective: To study systemic lupus erythematosus in a Brazilian population using the American College of Rheumatology hematological classification criteria and report associations of the disease with serological and clinical profiles. Methods: This is a retrospective study of 460 systemic lupus erythematosus patients followed in a single rheumatologic center during the last 10 years. Hematological manifestations considered for this study were hemolysis, leukopenia, lymphocytopenia and thrombocytopenia. Results: The cumulative prevalences of leukopenia, thrombocytopenia, lymphocytopenia and hemolytic anemia were 29.8%, 21.08%, 17.7% and 8.4%, respectively. A higher percentage of patients with hemolysis had anticardiolipin IgM (p-value = 0.002). Those with leukopenia had more lymphopenia (p-value = 0.02), psychosis (p-value = 0.01), thrombocytopenia (p-value <0.0001) and anti-double stranded DNA antibodies (p-value = 0.03). Patients with lymphopenia had more leukopenia (OR = 1.8; 95% CI = 1.01–3.29) and lupus anticoagulant antibodies (OR = 2.2; 95% CI = 1.16–4.39) and those with thrombocytopenia had more leukopenia (OR = 3.1; 95% CI = 1.82–5.44) and antiphospholipid syndrome (OR = 3.1; 95% CI = 1.28–7.87). Conclusion: The most common hematological finding was leukopenia and the least common was hemolysis. Associations of low platelet count and hemolysis were found with antiphospholipid syndrome and anticardiolipin IgM positivity, respectively. Leukopenia and lymphocytopenia are correlated and leukopenia is more common in systemic lupus erythematosus patients with psychosis, thrombocytopenia and anti-double stranded DNA. o Bra © 2015 Associaçã ∗ Corresponding author at: Serviço de Reumatologia, Hospital Universitá igorrilho, Curitiba, PR, Brazil. E-mail address: [email protected] (T. Skare). ttp://dx.doi.org/10.1016/j.bjhh.2015.01.006 516-8484/© 2015 Associação Brasileira de Hematologia, Hemoterapia eserved. sileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. rio Evangélico de Curitiba, Rua Augusto Stellfeld, 1908, 80730-150 e Terapia Celular. Published by Elsevier Editora Ltda. All rights oter. Document downloaded from http://rbhh.elsevier.es/, day 30/06/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited. 116 rev bras hematol hem